Publication: CRISPR-Cas9 targeted disruption of the yellow ortholog in the housefly identifies the brown body locus
CRISPR-Cas9 targeted disruption of the yellow ortholog in the housefly identifies the brown body locus
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Heinze, S. D., Kohlbrenner, T., Ippolito, D., Meccariello, A., Burger, A., Mosimann, C., Saccone, G., & Bopp, D. (2017). CRISPR-Cas9 targeted disruption of the yellow ortholog in the housefly identifies the brown body locus. Scientific Reports, 7(1), e1–e9. https://doi.org/10.1038/s41598-017-04686-6
Abstract
Abstract
Abstract
The classic brown body (bwb) mutation in the housefly Musca domestica impairs normal melanization of the adult cuticle. In Drosophila melanogaster, a reminiscent pigmentation defect results from mutations in the yellow gene encoding dopachrome conversion enzyme (DCE). Here, we demonstrate that the bwb locus structurally and functionally represents the yellow ortholog of Musca domestica, MdY. In bwb Musca strains, we identified two mutant MdY alleles that contain lesions predicted to result in premature truncation of the MdY open readi
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Creators (Authors)
- Heinze, Svenia D
- Kohlbrenner, Tea
- Ippolito, Domenica
- Meccariello, Angela
- Burger, Alexa
- Saccone, Giuseppe
- Bopp, Daniel
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Citations
Heinze, S. D., Kohlbrenner, T., Ippolito, D., Meccariello, A., Burger, A., Mosimann, C., Saccone, G., & Bopp, D. (2017). CRISPR-Cas9 targeted disruption of the yellow ortholog in the housefly identifies the brown body locus. Scientific Reports, 7(1), e1–e9. https://doi.org/10.1038/s41598-017-04686-6
