Engineered Modular Adapters for Targeted Adenoviral Gene Delivery to Dendritic Cells with Implications for Tumor Vaccination

Abstract

Gene therapy is a medical intervention involving the delivery of genetic material. The aim is to induce the host cell to produce new proteins in situ, which will have a therapeutic effect. Gene therapy has a wide range of applications, including vaccines, gene editors and monoclonal antibodies. Adenoviral vectors (AdV) are the most commonly used delivery system for gene therapy due to a number of beneficial characteristics: (i) extensive research provides a clear understanding of their interaction with human host factors, (ii) the abi Show more