Publication: Influence of hepatic and intestinal efflux transporters and their genetic variants on the pharmacokinetics and pharmacodynamics of raloxifene in osteoporosis treatment
Date
Date
Date
2012
Journal Article
Published version
Abstract
Abstract
Abstract
Raloxifene exhibits a large and unexplained interindividual variability in its pharmacokinetics and pharmacodynamics. The aim of our study was to identify transporters involved in the efflux of raloxifene and its glucuronide metabolites by various in vitro models and by an in vivo study to explore the possible involvement of P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP)1, MRP2, MRP3, and breast cancer resistance protein in the observed high interindividual variability. Experiments with the parallel artificial mem
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7 since deposited on 2012-12-29
Acq. date: 2025-11-12
Views
1 since deposited on 2012-12-29
Acq. date: 2025-11-12
Additional indexing
Creators (Authors)
- Trdan Lušin, Tina
- Mrhar, Aleš
- Stieger, Bruno
- Kullak-Ublick, Gerd A
- Marc, Janja
- Ostanek, Barbara
- Zavratnik, Andrej
- Kristl, Albin
- Berginc, Katja
- Delić, Katja
- Trontelj, Jurij
Volume
Volume
Volume
160
Number
Number
Number
4
Page range/Item number
Page range/Item number
Page range/Item number
298
Page end
Page end
Page end
308
Item Type
Item Type
Item Type
Journal Article
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Language
Language
Language
English
Publication date
Publication date
Publication date
2012
Date available
Date available
Date available
2012-12-29
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
1878-1810
OA Status
OA Status
OA Status
Green
Publisher DOI
Metrics
Downloads
7 since deposited on 2012-12-29
Acq. date: 2025-11-12
Views
1 since deposited on 2012-12-29
Acq. date: 2025-11-12
Green Open Access
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