Publication: Cross-species evaluation of fibroblast activation protein alpha as potential imaging target for soft tissue sarcoma: a comparative immunohistochemical study in humans, dogs, and cats
Cross-species evaluation of fibroblast activation protein alpha as potential imaging target for soft tissue sarcoma: a comparative immunohistochemical study in humans, dogs, and cats
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Beer, P., Pauli, C., Haberecker, M., Grest, P., Beebe, E., Fuchs, D., Markkanen, E., Krudewig, C., & Nolff, M. C. (2023). Cross-species evaluation of fibroblast activation protein alpha as potential imaging target for soft tissue sarcoma: a comparative immunohistochemical study in humans, dogs, and cats. Frontiers in Oncology, 13, 1210004. https://doi.org/10.3389/fonc.2023.1210004
Abstract
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Abstract
INTRODUCTION: Complete surgical tumor resection is paramount in the management of soft tissue sarcoma (STS) in humans, dogs, and cats alike. Near-infrared targeted tracers for fluorescence-guided surgery (FGS) could facilitate intraoperative visualization of the tumor and improve resection accuracy. Target identification is complicated in STS due to the rarity and heterogeneity of the disease. This study aims to validate the expression of fibroblast activation protein alpha (FAP) in selected human, canine, and feline STS subtypes to a
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- Beer, Patricia
- Pauli, Chantal
- Haberecker, Martina
- Grest, Paula
- Beebe, Erin
- Fuchs, Daniel
- Krudewig, Christiane
- Nolff, Mirja Christine
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Beer, P., Pauli, C., Haberecker, M., Grest, P., Beebe, E., Fuchs, D., Markkanen, E., Krudewig, C., & Nolff, M. C. (2023). Cross-species evaluation of fibroblast activation protein alpha as potential imaging target for soft tissue sarcoma: a comparative immunohistochemical study in humans, dogs, and cats. Frontiers in Oncology, 13, 1210004. https://doi.org/10.3389/fonc.2023.1210004
