Publication: Nucleotide sequence, chromosomal assignment and mRNA expression of mouse hypoxia-inducible factor-1 alpha.
Nucleotide sequence, chromosomal assignment and mRNA expression of mouse hypoxia-inducible factor-1 alpha.
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Wenger, R. H., Rolfs, A., Marti, H. H., Guénet, J. L., & Gassmann, M. (1996). Nucleotide sequence, chromosomal assignment and mRNA expression of mouse hypoxia-inducible factor-1 alpha. Biochemical and Biophysical Research Communications, 223, 54–59. https://doi.org/10.1006/bbrc.1996.0845
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The heterodimeric hypoxia-inducible transcription factor HIF-1 is involved in the oxygen-regulated transcription of several genes including erythropoietin. Cloning and sequencing of the alpha-subunit of mouse HIF-1 cDNA revealed a 90% overall homology to human HIF-l alpha but lack of any similarity in the 5' untranslated region and translational start site. Mouse HIF-1 alpha is encoded by an evolutionary conserved single-copy gene located on chromosome 12. We found a widespread constitutive expression of mouse HIf-1 alpha mRNA which w
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Wenger, R. H., Rolfs, A., Marti, H. H., Guénet, J. L., & Gassmann, M. (1996). Nucleotide sequence, chromosomal assignment and mRNA expression of mouse hypoxia-inducible factor-1 alpha. Biochemical and Biophysical Research Communications, 223, 54–59. https://doi.org/10.1006/bbrc.1996.0845