Publication: Neuroprotection with the P53-Inhibitor Pifithrin-μ after Cardiac Arrest in a Rodent Model
Neuroprotection with the P53-Inhibitor Pifithrin-μ after Cardiac Arrest in a Rodent Model
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Glas, M., Frick, T., Springe, D., Putzu, A., Zuercher, P., Grandgirard, D., Leib, S. L., Jakob, S. M., Takala, J., & Haenggi, M. (2018). Neuroprotection with the P53-Inhibitor Pifithrin-μ after Cardiac Arrest in a Rodent Model. Shock, 49(2), 229–234. https://doi.org/10.1097/SHK.0000000000000917
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BACKGROUND The small molecule pifithrin-μ reversibility inhibits the mitochondrial pathway of apoptosis. The neuronal effects of pifithrin-μ applied after cardiac arrest are unknown. We hypothesized that pifithrin-μ reduces neuronal damage in the most vulnerable brain region, the hippocampus, after cardiac arrest. METHODS In two randomized controlled series we administered pifithrin-μ or control in 109 rats resuscitated after 8 or 10 min of cardiac arrest. Neuronal damage was blindly assessed with histology (Fluoro Jade B: FJB, cre
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- Glas, Michael
- Frick, Tamara
- Springe, Dirk
- Putzu, Alessandro
- Zuercher, Patrick
- Grandgirard, Denis
- Leib, Stephen L
- Jakob, Stephan M
- Takala, Jukka
- Haenggi, Matthias
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Glas, M., Frick, T., Springe, D., Putzu, A., Zuercher, P., Grandgirard, D., Leib, S. L., Jakob, S. M., Takala, J., & Haenggi, M. (2018). Neuroprotection with the P53-Inhibitor Pifithrin-μ after Cardiac Arrest in a Rodent Model. Shock, 49(2), 229–234. https://doi.org/10.1097/SHK.0000000000000917
