Publication: Identification of hMutLbeta, a heterodimer of hMLH1 and hPMS1
Identification of hMutLbeta, a heterodimer of hMLH1 and hPMS1
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Räschle, M., Marra, G., Nyström-Lahti, M., Schär, P., & Jiricny, J. (1999). Identification of hMutLbeta, a heterodimer of hMLH1 and hPMS1. Journal of Biological Chemistry, 274(45), 32368–32375. https://doi.org/10.1074/jbc.274.45.32368
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hMLH1 and hPMS2 function in postreplicative mismatch repair in the form of a heterodimer referred to as hMutLalpha. Tumors or cell lines lacking this factor display mutator phenotypes and microsatellite instability, and mutations in the hMLH1 and hPMS2 genes predispose to hereditary non-polyposis colon cancer. A third MutL homologue, hPMS1, has also been reported to be mutated in one cancer-prone kindred, but the protein encoded by this locus has so far remained without function. We now show that hPMS1 is expressed in human cells and
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- Räschle, M
- Marra, Giancarlo
- Nyström-Lahti, M
- Schär, P
- Jiricny, J
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Räschle, M., Marra, G., Nyström-Lahti, M., Schär, P., & Jiricny, J. (1999). Identification of hMutLbeta, a heterodimer of hMLH1 and hPMS1. Journal of Biological Chemistry, 274(45), 32368–32375. https://doi.org/10.1074/jbc.274.45.32368
