Publication: microRNA-192 suppresses the expression of the farnesoid X receptor
microRNA-192 suppresses the expression of the farnesoid X receptor
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Krattinger, R., Boström, A., Schiöth, H. B., Thasler, W. E., Mwinyi, J., & Kullak-Ublick, G. A. (2016). microRNA-192 suppresses the expression of the farnesoid X receptor. American Journal Of Physiology. Gastrointestinal And Liver Physiology, 310(11), G1044–G1051. https://doi.org/10.1152/ajpgi.00297.2015
Abstract
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Farnesoid X receptor (FXR, NR1H4) plays an important role in the regulation of bile acid homeostasis in liver and intestine and may exert protective effects against certain forms of cancer such as colon carcinoma. However, the role of FXR in cell growth regulation, apoptosis, and carcinogenesis is still controversial. Similar to FXR, microRNA-192 (miR-192) is mainly expressed in the liver and colon and plays an important role in the pathogenesis of colon carcinoma. In this study, we investigated the extent to which FXR is regulated by
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- Krattinger, Regina
- Boström, Adrian
- Schiöth, Helgi B
- Thasler, Wolfgang E
- Mwinyi, Jessica
- Kullak-Ublick, Gerd A
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Citations
Krattinger, R., Boström, A., Schiöth, H. B., Thasler, W. E., Mwinyi, J., & Kullak-Ublick, G. A. (2016). microRNA-192 suppresses the expression of the farnesoid X receptor. American Journal Of Physiology. Gastrointestinal And Liver Physiology, 310(11), G1044–G1051. https://doi.org/10.1152/ajpgi.00297.2015
