Publication: PD-1 checkpoint inhibition enhances the antilymphoma activity of CD19-CAR-iNKT cells that retain their ability to prevent alloreactivity
PD-1 checkpoint inhibition enhances the antilymphoma activity of CD19-CAR-iNKT cells that retain their ability to prevent alloreactivity
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Moraes Ribeiro, E., Secker, K.-A., Nitulescu, A.-M., Schairer, R., Keppeler, H., Wesle, A., Schmid, H., Schmitt, A., Neuber, B., Chmiest, D., Podavini, S., Märklin, M., Klimovich, B., Schmitt, M., Korkmaz, F., Lengerke, C., Schneidawind, C., & Schneidawind, D. (2024). PD-1 checkpoint inhibition enhances the antilymphoma activity of CD19-CAR-iNKT cells that retain their ability to prevent alloreactivity. Journal for ImmunoTherapy of Cancer, 12(1), e007829. https://doi.org/10.1136/jitc-2023-007829
Abstract
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Abstract
BACKGROUND
Relapse and graft-versus-host disease (GVHD) are the main causes of death after allogeneic hematopoietic cell transplantation (HCT). Preclinical murine models and clinical data suggest that invariant natural killer T (iNKT) cells prevent acute and chronic GVHD. In addition, iNKT cells are crucial for efficient immune responses against malignancies and contribute to reduced relapse rates after transplantation. Chimeric antigen receptors (CAR) redirect effector cells to cell surface antigens and enhance killing of target cel
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Creators (Authors)
- Moraes Ribeiro, Emmanuelle
- Secker, Kathy-Ann
- Nitulescu, Ana-Maria
- Schairer, Rebekka
- Keppeler, Hildegard
- Wesle, Anton
- Schmid, Hannes
- Schmitt, Anita
- Neuber, Brigitte
- Chmiest, Daniela
- Podavini, Silvia
- Märklin, Melanie
- Klimovich, Boris
- Schmitt, Michael
- Korkmaz, Fulya
- Lengerke, Claudia
- Schneidawind, Corina
- Schneidawind, Dominik
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Moraes Ribeiro, E., Secker, K.-A., Nitulescu, A.-M., Schairer, R., Keppeler, H., Wesle, A., Schmid, H., Schmitt, A., Neuber, B., Chmiest, D., Podavini, S., Märklin, M., Klimovich, B., Schmitt, M., Korkmaz, F., Lengerke, C., Schneidawind, C., & Schneidawind, D. (2024). PD-1 checkpoint inhibition enhances the antilymphoma activity of CD19-CAR-iNKT cells that retain their ability to prevent alloreactivity. Journal for ImmunoTherapy of Cancer, 12(1), e007829. https://doi.org/10.1136/jitc-2023-007829
