Publication: Functional Polarity of Microvascular Brain Endothelial Cells Supported by Neurovascular Unit Computational Model of Large Neutral Amino Acid Homeostasis
Functional Polarity of Microvascular Brain Endothelial Cells Supported by Neurovascular Unit Computational Model of Large Neutral Amino Acid Homeostasis
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Taslimifar, M., Buoso, S., Verrey, F., & Kurtcuoglu, V. (2018). Functional Polarity of Microvascular Brain Endothelial Cells Supported by Neurovascular Unit Computational Model of Large Neutral Amino Acid Homeostasis. Frontiers in Physiology, 9, 171. https://doi.org/10.3389/fphys.2018.00171
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The homeostatic regulation of large neutral amino acid (LNAA) concentration in the brain interstitial fluid (ISF) is essential for proper brain function. LNAA passage into the brain is primarily mediated by the complex and dynamic interactions between various solute carrier (SLC) transporters expressed in the neurovascular unit (NVU), among which SLC7A5/LAT1 is considered to be the major contributor in microvascular brain endothelial cells (MBEC). The LAT1-mediated trans-endothelial transport of LNAAs, however, could not be characteri
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- Taslimifar, Mehdi
- Buoso, Stefano
- Verrey, Francois
- Kurtcuoglu, Vartan
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Taslimifar, M., Buoso, S., Verrey, F., & Kurtcuoglu, V. (2018). Functional Polarity of Microvascular Brain Endothelial Cells Supported by Neurovascular Unit Computational Model of Large Neutral Amino Acid Homeostasis. Frontiers in Physiology, 9, 171. https://doi.org/10.3389/fphys.2018.00171
