Clinical effects of probiotic or azithromycin as an adjunct to scaling and root planning in the treatment of stage III periodontitis: a pilot randomized controlled clinical trial

Morales, Alicia; Contador, Rafael; Bravo, Joel; Carvajal, Paola; Silva, Nora; Strauss, Franz-Josef; Gamonal, Jorge

doi:10.1186/s12903-020-01276-3

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Morales, A., Contador, R., Bravo, J., Carvajal, P., Silva, N., Strauss, F.-J., & Gamonal, J. (2021). Clinical effects of probiotic or azithromycin as an adjunct to scaling and root planning in the treatment of stage III periodontitis: a pilot randomized controlled clinical trial. BMC Oral Health, 21, 12. https://doi.org/10.1186/s12903-020-01276-3

Abstract

BACKGROUND The aim of this triple-blind placebo-controlled parallel-arm randomized clinical trial was to evaluate the clinical effects of Lactobacillus rhamnosus SP1 or azithromycin as an adjunct to scaling and root planing (SRP) in patients with stage III periodontitis. METHODS Forty-seven systemically healthy participants with stage III periodontitis were recruited. Following SRP, the participants were randomly assigned to one of three treatment modalities; (1) placebo (n = 15), (2) probiotics (n = 16) and (3) antibiotics-azithromyc