Publication: Pitfalls in the assessment of MGMT expression and in its correlation with survival in diffuse astrocytomas: proposal of a feasible immunohistochemical approach
Pitfalls in the assessment of MGMT expression and in its correlation with survival in diffuse astrocytomas: proposal of a feasible immunohistochemical approach
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Capper, D., Mittelbronn, M., Meyermann, R., & Schittenhelm, J. (2008). Pitfalls in the assessment of MGMT expression and in its correlation with survival in diffuse astrocytomas: proposal of a feasible immunohistochemical approach. Acta Neuropathologica, 115(2), 249–259. https://doi.org/10.1007/s00401-007-0310-x
Abstract
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Abstract
Immunohistochemical studies showed that O6-methylguanine-DNA methyltransferase (MGMT) protein expression is negatively associated with survival in glioblastomas treated with alkylating agents in accordance with previous results of methylation-specific PCR. Implementation of this data in routine clinical diagnostics is limited due to often inappropriate study designs, e.g. pooling of tumor entities, WHO grades or primary and secondary glioblastomas, disregard concerning the infiltration zone or various epidemiological factors. The aim
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- Capper, David
- Mittelbronn, Michel
- Meyermann, Richard
- Schittenhelm, Jens
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Capper, D., Mittelbronn, M., Meyermann, R., & Schittenhelm, J. (2008). Pitfalls in the assessment of MGMT expression and in its correlation with survival in diffuse astrocytomas: proposal of a feasible immunohistochemical approach. Acta Neuropathologica, 115(2), 249–259. https://doi.org/10.1007/s00401-007-0310-x
