Publication: JAK1-dependent transphosphorylation of JAK2 limits the antifibrotic effects of selective JAK2 inhibitors on long-term treatment
JAK1-dependent transphosphorylation of JAK2 limits the antifibrotic effects of selective JAK2 inhibitors on long-term treatment
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Zhang, Y., Liang, R., Chen, C.-W., Mallano, T., Dees, C., Distler, A., Reich, A., Bergmann, C., Ramming, A., Gelse, K., Mielenz, D., Distler, O., Schett, G., & Distler, J. H. W. (2017). JAK1-dependent transphosphorylation of JAK2 limits the antifibrotic effects of selective JAK2 inhibitors on long-term treatment. Annals of the Rheumatic Diseases, 76(8), 1467–1475. https://doi.org/10.1136/annrheumdis-2016-210911
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Abstract
OBJECTIVES: Janus kinase 2 (JAK2) has recently been described as a novel downstream mediator of the pro-fibrotic effects of transforming growth factor-β. Although JAK2 inhibitors are in clinical use for myelodysplastic syndromes, patients often rapidly develop resistance. Tumour cells can escape the therapeutic effects of selective JAK2 inhibitors by mutation-independent transactivation of JAK2 by JAK1. Here, we used selective JAK2 inhibition as a model to test the hypothesis that chronic treatment may provoke resistance by facilitati
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Creators (Authors)
- Zhang, Yun
- Liang, Ruifang
- Chen, Chih-Wei
- Mallano, Tatjana
- Dees, Clara
- Distler, Alfiya
- Reich, Adam
- Bergmann, Christina
- Ramming, Andreas
- Gelse, Kolja
- Mielenz, Dirk
- Distler, Oliver
- Schett, Georg
- Distler, Jörg H W
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Zhang, Y., Liang, R., Chen, C.-W., Mallano, T., Dees, C., Distler, A., Reich, A., Bergmann, C., Ramming, A., Gelse, K., Mielenz, D., Distler, O., Schett, G., & Distler, J. H. W. (2017). JAK1-dependent transphosphorylation of JAK2 limits the antifibrotic effects of selective JAK2 inhibitors on long-term treatment. Annals of the Rheumatic Diseases, 76(8), 1467–1475. https://doi.org/10.1136/annrheumdis-2016-210911