Publication: Microcephalin and pericentrin regulate mitotic entry via centrosome-associated Chk1
Microcephalin and pericentrin regulate mitotic entry via centrosome-associated Chk1
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Tibelius, A., Marhold, J., Zentgraf, H., Heilig, C. E., Neitzel, H., Ducommun, B., Rauch, A., Ho, A. D., Bartek, J., & Krämer, A. (2009). Microcephalin and pericentrin regulate mitotic entry via centrosome-associated Chk1. Journal of Cell Biology, 185, 1149–1157. https://doi.org/10.1083/jcb.200810159
Abstract
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Abstract
Primary microcephaly, Seckel syndrome, and microcephalic osteodysplastic primordial dwarfism type II (MOPD II) are disorders exhibiting marked microcephaly, with small brain sizes reflecting reduced neuron production during fetal life. Although primary microcephaly can be caused by mutations in microcephalin (MCPH1), cells from patients with Seckel syndrome and MOPD II harbor mutations in ataxia telangiectasia and Rad3 related (ATR) or pericentrin (PCNT), leading to disturbed ATR signaling. In this study, we show that a lack of MCPH1
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- Tibelius, A
- Marhold, J
- Zentgraf, H
- Heilig, C E
- Neitzel, H
- Ducommun, B
- Rauch, A
- Ho, A D
- Bartek, J
- Krämer, A
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Tibelius, A., Marhold, J., Zentgraf, H., Heilig, C. E., Neitzel, H., Ducommun, B., Rauch, A., Ho, A. D., Bartek, J., & Krämer, A. (2009). Microcephalin and pericentrin regulate mitotic entry via centrosome-associated Chk1. Journal of Cell Biology, 185, 1149–1157. https://doi.org/10.1083/jcb.200810159
