Publication: Proteomic-based stratification of intermediate-risk prostate cancer patients
Proteomic-based stratification of intermediate-risk prostate cancer patients
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Zhong, Q., Sun, R., Aref, A. T., Noor, Z., Anees, A., Zhu, Y., Lucas, N., Poulos, R. C., Lyu, M., Zhu, T., Chen, G.-B., Wang, Y., Ding, X., Rutishauser, D., Rupp, N. J., Rueschoff, J. H., Poyet, C., Hermanns, T., Fankhauser, C., … Wild, P. J. (2024). Proteomic-based stratification of intermediate-risk prostate cancer patients. Life Science Alliance, 7(2), e202302146. https://doi.org/10.26508/lsa.202302146
Abstract
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Abstract
Gleason grading is an important prognostic indicator for prostate adenocarcinoma and is crucial for patient treatment decisions. However, intermediate-risk patients diagnosed in the Gleason grade group (GG) 2 and GG3 can harbour either aggressive or non-aggressive disease, resulting in under- or overtreatment of a significant number of patients. Here, we performed proteomic, differential expression, machine learning, and survival analyses for 1,348 matched tumour and benign sample runs from 278 patients. Three proteins (F5, TMEM126B,
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Creators (Authors)
- Zhong, Qing
- Sun, Rui
- Aref, Adel T
- Noor, Zainab
- Anees, Asim
- Zhu, Yi
- Lucas, Natasha
- Poulos, Rebecca C
- Lyu, Mengge
- Zhu, Tiansheng
- Chen, Guo-Bo
- Wang, Yingrui
- Ding, Xuan
- Rutishauser, Dorothea
- Rupp, Niels J
- Rueschoff, Jan H
- Poyet, Cédric
- Hermanns, Thomas
- Fankhauser, Christian
- Rodríguez Martínez, María
- Shao, Wenguang
- Buljan, Marija
- Neumann, Janis Frederick
- Beyer, Andreas
- Hains, Peter G
- Reddel, Roger R
- Robinson, Phillip J
- Aebersold, Ruedi
- Guo, Tiannan
- Wild, Peter J
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Zhong, Q., Sun, R., Aref, A. T., Noor, Z., Anees, A., Zhu, Y., Lucas, N., Poulos, R. C., Lyu, M., Zhu, T., Chen, G.-B., Wang, Y., Ding, X., Rutishauser, D., Rupp, N. J., Rueschoff, J. H., Poyet, C., Hermanns, T., Fankhauser, C., … Wild, P. J. (2024). Proteomic-based stratification of intermediate-risk prostate cancer patients. Life Science Alliance, 7(2), e202302146. https://doi.org/10.26508/lsa.202302146
