Publication: Synthesis of a polymyxin derivative for photolabeling studies in the gram-negative bacterium Escherichia coli
Synthesis of a polymyxin derivative for photolabeling studies in the gram-negative bacterium Escherichia coli
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Robinson, J. A., & van der Meijden, B. (2015). Synthesis of a polymyxin derivative for photolabeling studies in the gram-negative bacterium Escherichia coli. Journal of Peptide Science, 21(3), 231–235. https://doi.org/10.1002/psc.2736
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The antimicrobial activity of polymyxins against Gram-negative bacteria has been known for several decades, but the mechanism of action leading to cell death has not been fully explored. A key step after binding of the antibiotic to lipopolysaccharide (LPS) exposed at the cell surface is 'self-promoted uptake' across the outer membrane (OM), in which the antibiotic traverses the asymmetric LPS-phospholipid bilayer before reaching the periplasm and finally targeting and disrupting the bacterial phospholipid inner membrane. The work des
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- Robinson, J A
- van der Meijden, B
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Robinson, J. A., & van der Meijden, B. (2015). Synthesis of a polymyxin derivative for photolabeling studies in the gram-negative bacterium Escherichia coli. Journal of Peptide Science, 21(3), 231–235. https://doi.org/10.1002/psc.2736
