Analysis of the frequency of oncogenic driver mutations and correlation with clinicopathological characteristics in patients with lung adenocarcinoma from Northeastern Switzerland

Grosse, Alexandra; Grosse, Claudia; Rechsteiner, Markus; Soltermann, Alex

doi:10.1186/s13000-019-0789-1

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Grosse, A., Grosse, C., Rechsteiner, M., & Soltermann, A. (2019). Analysis of the frequency of oncogenic driver mutations and correlation with clinicopathological characteristics in patients with lung adenocarcinoma from Northeastern Switzerland. Diagnostic Pathology, 14(1), 18. https://doi.org/10.1186/s13000-019-0789-1

Abstract

BACKGROUND

Molecular testing of lung adenocarcinoma for oncogenic driver mutations has become standard in pathology practice. The aim of the study was to analyze the EGFR, KRAS, ALK, RET, ROS1, BRAF, ERBB2, MET and PIK3CA mutational status in a representative cohort of Swiss patients with lung adenocarcinoma and to correlate the mutational status with clinicopathological patient characteristics.

METHODS

All patients who underwent molecular testing of newly diagnosed lung adenocarcinoma during a 4-year period (2014-2018) were includ