Publication: Inhaled dry powder mannitol in children with cystic fibrosis: A randomised efficacy and safety trial
Inhaled dry powder mannitol in children with cystic fibrosis: A randomised efficacy and safety trial
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De Boeck, K., Haarman, E., Hull, J., Lands, L. C., Moeller, A., Munck, A., Riethmüller, J., Tiddens, H., Volpi, S., Leadbetter, J., Charlton, B., & Malfroot, A. (2017). Inhaled dry powder mannitol in children with cystic fibrosis: A randomised efficacy and safety trial. Journal of Cystic Fibrosis, 16(3), 380–387. https://doi.org/10.1016/j.jcf.2017.02.003
Abstract
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Abstract
INTRODUCTION: Inhaled mannitol has beneficial effects on lung function, mucociliary clearance, quality of life and sputum properties. This trial examined the efficacy of inhaled mannitol in children with cystic fibrosis (CF). METHODS: The efficacy of inhaled mannitol in children with CF aged 6-17years was assessed in a phase 2, randomised, placebo-controlled crossover study. Subjects were randomly assigned to mannitol 400mg every 12h or matching placebo for 8weeks, followed by an 8week washout and an 8week period with the alternate tr
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- De Boeck, K
- Haarman, E
- Hull, J
- Lands, L C
- Moeller, Alexander
- Munck, A
- Riethmüller, J
- Tiddens, H
- Volpi, S
- Leadbetter, J
- Charlton, B
- Malfroot, A
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De Boeck, K., Haarman, E., Hull, J., Lands, L. C., Moeller, A., Munck, A., Riethmüller, J., Tiddens, H., Volpi, S., Leadbetter, J., Charlton, B., & Malfroot, A. (2017). Inhaled dry powder mannitol in children with cystic fibrosis: A randomised efficacy and safety trial. Journal of Cystic Fibrosis, 16(3), 380–387. https://doi.org/10.1016/j.jcf.2017.02.003