Publication: Effects of Strontium-Doped β-Tricalcium Scaffold on Longitudinal Nuclear Factor-Kappa Beta and Vascular Endothelial Growth Factor Receptor-2 Promoter Activities during Healing in a Murine Critical-Size Bone Defect Model
Effects of Strontium-Doped β-Tricalcium Scaffold on Longitudinal Nuclear Factor-Kappa Beta and Vascular Endothelial Growth Factor Receptor-2 Promoter Activities during Healing in a Murine Critical-Size Bone Defect Model
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Tohidnezhad, M., Kubo, Y., Lichte, P., Heigl, T., Roch, D., Barahmand Pour, N., Bergmann, C., Sönmez, T. T., Hock, J. V. P., Fragoulis, A., Gremse, F., Rosenhain, S., Slowik, A., Bienert, M., Kweider, N., Wruck, C. J., Jahr, H., Hildebrand, F., Pape, H. C., … Pufe, T. (2020). Effects of Strontium-Doped β-Tricalcium Scaffold on Longitudinal Nuclear Factor-Kappa Beta and Vascular Endothelial Growth Factor Receptor-2 Promoter Activities during Healing in a Murine Critical-Size Bone Defect Model. International Journal of Molecular Sciences, 21(9), 1–19. https://doi.org/10.3390/ijms21093208
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It was hypothesized that strontium (Sr)-doped β-tricalcium phosphate (TCP)-based scaffolds have a positive effect on the regeneration of large bone defects (LBD). Readouts in our mice models were nuclear factor-kappa beta (NF-κB) activity and vascular endothelial growth factor receptor-2 (VEGFR-2) promoter activity during the healing process. A 2-mm critical-size femoral fracture was performed in transgenic NF-κB- and VEGFR-2-luciferase reporter mice. The fracture was filled with a 3D-printed β-TCP scaffold with or without Sr. A biolu
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- Tohidnezhad, Mersedeh
- Kubo, Yusuke
- Lichte, Philipp
- Heigl, Tobias
- Roch, Diana
- Barahmand Pour, Nazanin
- Bergmann, Christian
- Sönmez, Tolga Taha
- Hock, Jennifer Vanessa Phi
- Fragoulis, Athanassios
- Gremse, Felix
- Rosenhain, Stefanie
- Slowik, Alexander
- Bienert, Michaela
- Kweider, Nisreen
- Wruck, Christoph Jan
- Jahr, Holger
- Hildebrand, Frank
- Pape, Hans Christoph
- Neuß, Sabine
- Fischer, Horst
- Pufe, Thomas
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Tohidnezhad, M., Kubo, Y., Lichte, P., Heigl, T., Roch, D., Barahmand Pour, N., Bergmann, C., Sönmez, T. T., Hock, J. V. P., Fragoulis, A., Gremse, F., Rosenhain, S., Slowik, A., Bienert, M., Kweider, N., Wruck, C. J., Jahr, H., Hildebrand, F., Pape, H. C., … Pufe, T. (2020). Effects of Strontium-Doped β-Tricalcium Scaffold on Longitudinal Nuclear Factor-Kappa Beta and Vascular Endothelial Growth Factor Receptor-2 Promoter Activities during Healing in a Murine Critical-Size Bone Defect Model. International Journal of Molecular Sciences, 21(9), 1–19. https://doi.org/10.3390/ijms21093208
