Publication: Two dose investigation of the 5-HT-agonist psilocybin on relative and global cerebral blood flow
Two dose investigation of the 5-HT-agonist psilocybin on relative and global cerebral blood flow
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Lewis, C. R., Preller, K. H., Kraehenmann, R., Michels, L., Staempfli, P., & Vollenweider, F. X. (2017). Two dose investigation of the 5-HT-agonist psilocybin on relative and global cerebral blood flow. NeuroImage, 159, 70–78. https://doi.org/10.1016/j.neuroimage.2017.07.020
Abstract
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Abstract
Psilocybin, the active compound in psychedelic mushrooms, is an agonist of various serotonin receptors. Seminal psilocybin positron emission tomography (PET) research suggested regional increases in glucose metabolism in frontal cortex (hyperfrontality). However, a recent arterial spin labeling (ASL) study suggests psilocybin may lead to hypo-perfusion in various brain regions. In this placebo-controlled, double-blind study we used pseudo-continuous ASL (pCASL) to measure perfusion changes, with and without adjustment for global brain
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- Lewis, Candace R
- Kraehenmann, Rainer
- Michels, Lars
- Staempfli, Philipp
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Lewis, C. R., Preller, K. H., Kraehenmann, R., Michels, L., Staempfli, P., & Vollenweider, F. X. (2017). Two dose investigation of the 5-HT-agonist psilocybin on relative and global cerebral blood flow. NeuroImage, 159, 70–78. https://doi.org/10.1016/j.neuroimage.2017.07.020
