Publication: Using viral diversity to identify HIV-1 variants under HLA-dependent selection in a systematic viral genome-wide screen
Using viral diversity to identify HIV-1 variants under HLA-dependent selection in a systematic viral genome-wide screen
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Neuner-Jehle, N., Zeeb, M., Thorball, C. W., Fellay, J., Metzner, K. J., Frischknecht, P., Neumann, K., Leeman, C., Rauch, A., Stöckle, M., Huber, M., Perreau, M., Bernasconi, E., Notter, J., Hoffmann, M., Leuzinger, K., Günthard, H. F., Pasin, C., Kouyos, R. D., & Swiss HIV Cohort Study (SHCS). (2024). Using viral diversity to identify HIV-1 variants under HLA-dependent selection in a systematic viral genome-wide screen. PLoS Pathogens, 20(8), e1012385. https://doi.org/10.1371/journal.ppat.1012385
Abstract
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Abstract
The pathogenesis of HIV-1 infection is governed by a highly dynamic, time-dependent interaction between the host and the viral genome. In this study, we developed a novel systematic approach to assess the host-virus interaction, using average pairwise viral diversity as a proxy for time since infection, and applied this method to nearly whole viral genome sequences (n = 4,464), human leukocyte antigen (HLA) genotyping data (n = 1,044), and viral RNA load (VL) measurements during the untreated chronic phase (n = 829) of Swiss HIV Cohor
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Creators (Authors)
- Neuner-Jehle, Nadia
- Zeeb, Marius
- Thorball, Christian W
- Fellay, Jacques
- Metzner, Karin J
- Frischknecht, Paul
- Neumann, Kathrin
- Leeman, Christine
- Rauch, Andri
- Stöckle, Marcel
- Perreau, Matthieu
- Bernasconi, Enos
- Notter, Julia
- Hoffmann, Matthias
- Leuzinger, Karoline
- Günthard, Huldrych F
- Pasin, Chloé
- Kouyos, Roger D
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Neuner-Jehle, N., Zeeb, M., Thorball, C. W., Fellay, J., Metzner, K. J., Frischknecht, P., Neumann, K., Leeman, C., Rauch, A., Stöckle, M., Huber, M., Perreau, M., Bernasconi, E., Notter, J., Hoffmann, M., Leuzinger, K., Günthard, H. F., Pasin, C., Kouyos, R. D., & Swiss HIV Cohort Study (SHCS). (2024). Using viral diversity to identify HIV-1 variants under HLA-dependent selection in a systematic viral genome-wide screen. PLoS Pathogens, 20(8), e1012385. https://doi.org/10.1371/journal.ppat.1012385
