Publication: Differential expression and activity of 11beta-hydroxysteroid dehydrogenase in human placenta and fetal membranes from pregnancies with intrauterine growth restriction
Differential expression and activity of 11beta-hydroxysteroid dehydrogenase in human placenta and fetal membranes from pregnancies with intrauterine growth restriction
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Wächter, R., Masarik, L., Bürzle, M., Mallik, A., & von Mandach, U. (2009). Differential expression and activity of 11beta-hydroxysteroid dehydrogenase in human placenta and fetal membranes from pregnancies with intrauterine growth restriction. Fetal Diagnosis and Therapy, 25(3), 328–335. https://doi.org/10.1159/000235879
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OBJECTIVES: To study the expression and the function of the 11beta-hydroxysteroid dehydrogenase enzyme 1 (11beta-HSD1) and 2 (11beta-HSD2) in placenta and the fetal membranes from pregnancies with intrauterine growth restriction (IUGR) and from controls. METHODS: Amnion, chorion, decidua and cotyledon were separated from placenta; mRNA was analyzed by TaqMan real-time technology and proteins by Western blot; enzyme activities were measured by the conversion of 3H-cortisol to 3H-cortisone and vice versa. RESULTS: Predominant mRNA expre
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- Wächter, R
- Masarik, L
- Bürzle, M
- Mallik, A
- von Mandach, U
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Wächter, R., Masarik, L., Bürzle, M., Mallik, A., & von Mandach, U. (2009). Differential expression and activity of 11beta-hydroxysteroid dehydrogenase in human placenta and fetal membranes from pregnancies with intrauterine growth restriction. Fetal Diagnosis and Therapy, 25(3), 328–335. https://doi.org/10.1159/000235879
