Gut microbiota-derived metabolites contribute negatively to hindgut barrier function development at the early weaning goat model

Ke, Zhang; Zu, Yangbin; Yang, Yuxin; Guo, Mengmeng; Zhang, Ting; Zong, Bo; Huang, Shuhong; Suo, Langda; Ma, Buoha; Wang, Xiaolong; Wu, Yujiang; Brugger, Daniel; Chen, Yulin

doi:10.1016/j.aninu.2022.04.004

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Ke, Z., Zu, Y., Yang, Y., Guo, M., Zhang, T., Zong, B., Huang, S., Suo, L., Ma, B., Wang, X., Wu, Y., Brugger, D., & Chen, Y. (2022). Gut microbiota-derived metabolites contribute negatively to hindgut barrier function development at the early weaning goat model. Animal Nutrition, 10, 111–123. https://doi.org/10.1016/j.aninu.2022.04.004

Abstract

Early weaning induces intestinal injury, leading to a series of long-term symptoms such as inflammation, malabsorption and diarrhea. In this study, we hypothesized that microbes and their metabolites modulate the host's inflammatory response to early weaning stress in a goat model. A total of 18 female Tibetan goat kids (n = 9) were weaned from their mothers at 28 d (D28) and 60 d (D60) postpartum. D60 and D28 groups were fed the same solid diet ad libitum from weaning to 75 d of age. The colonic epithelium was subject to RNA-sequenci