Publication: FBH1 disrupts RAD51 filaments in vitro and modulates homologous recombination in mammalian cells
FBH1 disrupts RAD51 filaments in vitro and modulates homologous recombination in mammalian cells
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Simandlova, J., Zagelbaum, J., Payne, M. J., Chu, W. K., Shevelev, I., Hanada, K., Chatterjee, S., Reid, D. A., Liu, Y., Janscak, P., Rothenberg, E., & Hickson, I. D. (2013). FBH1 disrupts RAD51 filaments in vitro and modulates homologous recombination in mammalian cells. Journal of Biological Chemistry, 288, 34168–34180. https://doi.org/10.1074/jbc.M113.484493
Abstract
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Abstract
Efficient repair of DNA double-strand breaks and inter-strand cross-links requires the homologous recombination (HR) pathway, a potentially error-free process that utilizes a homologous sequence as a repair template. A key player in HR is RAD51, the eukaryotic ortholog of bacterial RecA protein. RAD51 can polymerize on DNA to form a nucleoprotein filament that facilitates both the search for the homologous DNA sequences and the subsequent DNA strand invasion required to initiate HR. Because of its pivotal role in HR, RAD51 is subject
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- Simandlova, Jitka
- Zagelbaum, Jen
- Payne, Miranda J
- Chu, Wai Kit
- Shevelev, Igor
- Hanada, Katsuhiro
- Chatterjee, Sujoy
- Reid, Dylan A
- Liu, Ying
- Janscak, Pavel
- Rothenberg, Eli
- Hickson, Ian D
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Simandlova, J., Zagelbaum, J., Payne, M. J., Chu, W. K., Shevelev, I., Hanada, K., Chatterjee, S., Reid, D. A., Liu, Y., Janscak, P., Rothenberg, E., & Hickson, I. D. (2013). FBH1 disrupts RAD51 filaments in vitro and modulates homologous recombination in mammalian cells. Journal of Biological Chemistry, 288, 34168–34180. https://doi.org/10.1074/jbc.M113.484493
