Bacteroides uniformis-induced perturbations in colonic microbiota and bile acid levels inhibit TH17 differentiation and ameliorate colitis developments

Yan, YiTing; Lei, Yu; Qu, Ying; Fan, Zhen; Xu, Yangbin; Du, Qian; Brugger, Daniel; Chen, Yulin; Zhang, Ke; Zhang, Enping

doi:10.1038/s41522-023-00420-5

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Yan, Y., Lei, Y., Qu, Y., Fan, Z., Xu, Y., Du, Q., Brugger, D., Chen, Y., Zhang, K., & Zhang, E. (2023). Bacteroides uniformis-induced perturbations in colonic microbiota and bile acid levels inhibit TH17 differentiation and ameliorate colitis developments. Npj Biofilms and Microbiomes, 9(1), 56. https://doi.org/10.1038/s41522-023-00420-5

Abstract

Inflammatory bowel disease (IBD) is associated with gut dysbiosis and can lead to colitis-associated malignancies. Bacteroides uniformis (Bu) regulates animal intestinal homeostasis; however, the mechanism by which it alleviates colitis in mice remains unknown. We investigated the effects of B. uniformis JCM5828 and its metabolites on female C57BL/6J mice with dextran sulfate sodium salt (DSS) induced colitis. Treatment with Bu considerably alleviated colitis progression and restored the mechanical and immune barrier protein expressio