Publication: Activation of feedforward wiring in adult hippocampal neurons by the basic-helix-loop-helix transcription factor Ascl4
Activation of feedforward wiring in adult hippocampal neurons by the basic-helix-loop-helix transcription factor Ascl4
Date
Date
Date
Citations
Luo, W., Egger, M., Cruz-Ochoa, N., Tse, A., Maloveczky, G., Tamás, B., Lukacsovich, D., Seng, C., Amrein, I., Lukacsovich, T., Wolfer, D., & Földy, C. (2024). Activation of feedforward wiring in adult hippocampal neurons by the basic-helix-loop-helix transcription factor Ascl4. PNAS Nexus, 3(5), pgae174. https://doi.org/10.1093/pnasnexus/pgae174
Abstract
Abstract
Abstract
Although evidence indicates that the adult brain retains a considerable capacity for circuit formation, adult wiring has not been broadly considered and remains poorly understood. In this study, we investigate wiring activation in adult neurons. We show that the basic-helix-loop-helix transcription factor Ascl4 can induce wiring in different types of hippocampal neurons of adult mice. The new axons are mainly feedforward and reconfigure synaptic weights in the circuit. Mice with the Ascl4-induced circuits do not display signs of patho
Metrics
Downloads
Views
Citations
Additional indexing
Creators (Authors)
- Luo, Wenshu
- Egger, Matteo
- Cruz-Ochoa, Natalia
- Tse, Alice
- Maloveczky, Gyula
- Tamás, Bálint
- Lukacsovich, David
- Seng, Charlotte
- Amrein, Irmgard
- Lukacsovich, Tamás
- Wolfer, David
- Földy, Csaba
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Item Type
Item Type
Item Type
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Metrics
Downloads
Views
Citations
Citations
Luo, W., Egger, M., Cruz-Ochoa, N., Tse, A., Maloveczky, G., Tamás, B., Lukacsovich, D., Seng, C., Amrein, I., Lukacsovich, T., Wolfer, D., & Földy, C. (2024). Activation of feedforward wiring in adult hippocampal neurons by the basic-helix-loop-helix transcription factor Ascl4. PNAS Nexus, 3(5), pgae174. https://doi.org/10.1093/pnasnexus/pgae174
