CCR7-guided neutrophil redirection to skin-draining lymph nodes regulates cutaneous inflammation and infection

Abstract

Draining lymph node neutrophils regulate inflammation Neutrophil recruitment to the draining lymph node is a crucial step in various skin-related immune responses; however, the mechanism by which this occurs is unclear. Here, Özcan et al. used various skin inflammation and infection models to track the movement of neutrophils homing to and leaving the skin. They found that the skin neutrophils migrated to the skin-draining lymph nodes in a CCR7-mediated manner. In the draining lymph node, neutrophils were cleared by phagocytosis by co Show more