Publication: No major effects of vitamin D3 (1,25 dihydroxyvitamin D3) on absorption and pharmacokinetics of folic acid and fexofenadine in healthy volunteers
No major effects of vitamin D3 (1,25 dihydroxyvitamin D3) on absorption and pharmacokinetics of folic acid and fexofenadine in healthy volunteers
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Kullak-Ublick, G. A., Gubler, C., Spanaus, K., Ismair, M. G., Claro da Silva, T., & Jetter, A. (2016). No major effects of vitamin D3 (1,25 dihydroxyvitamin D3) on absorption and pharmacokinetics of folic acid and fexofenadine in healthy volunteers. European Journal of Clinical Pharmacology, 72(7), 797–805. https://doi.org/10.1007/s00228-016-2050-0
Abstract
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PURPOSE: In Caco-2 cells, folate uptake via the proton-coupled folate transporter (PCFT) increases significantly by a 3-day treatment with 1,25-dihydroxyvitamin D3 (1,25(OH)2D3). Additionally, mRNA content and protein expression of the transporter OATP1A2 were increased up to ninefold with 1,25(OH)2D3. We investigated whether these in vitro findings can be confirmed in humans in vivo. METHODS: Ten healthy volunteers (six women) received 5 mg folic acid orally once before and once together with the last intake of a 10-day course of 0.5
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- Kullak-Ublick, Gerd A
- Gubler, Christoph
- Spanaus, Katharina
- Ismair, Manfred G
- Claro da Silva, Tatiana
- Jetter, Alexander
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Citations
Kullak-Ublick, G. A., Gubler, C., Spanaus, K., Ismair, M. G., Claro da Silva, T., & Jetter, A. (2016). No major effects of vitamin D3 (1,25 dihydroxyvitamin D3) on absorption and pharmacokinetics of folic acid and fexofenadine in healthy volunteers. European Journal of Clinical Pharmacology, 72(7), 797–805. https://doi.org/10.1007/s00228-016-2050-0
