A Systemic Wave of Neonatal Eosinophils Promotes Tissue Homeostasis and Commensalism

Abstract

The gastrointestinal (GI) tract poses a challenging site for the host immune system due to the high abundance of microbes in the gut lumen and continual exposure of foreign antigens that enter the gut through the diet. The transition from a relatively sterile environment of the womb to a world abundant with microbes requires the neonatal immune system to rapidly adapt and distinguish between harmful pathogens and harmless antigens, including beneficial commensal microbiota that colonizes the gut; laying the foundation for lifelong he Show more