Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome

Jain, Pritesh; Miller-Fleming, Tyne; Topaloudi, Apostolia; Yu, Dongmei; Drineas, Petros; Georgitsi, Marianthi; Yang, Zhiyu; Rizzo, Renata; Müller-Vahl, Kirsten R; Tumer, Zeynep; Mol Debes, Nanette; Hartmann, Andreas; Depienne, Christel; Worbe, Yulia; Mir, Pablo; Cath, Danielle C; Boomsma, Dorret I; Roessner, Veit; Wolanczyk, Tomasz; Janik, Piotr

doi:10.5167/uzh-232093

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Jain, P., Miller-Fleming, T., Topaloudi, A., Yu, D., Drineas, P., Georgitsi, M., Yang, Z., Rizzo, R., Müller-Vahl, K. R., Tumer, Z., Mol Debes, N., Hartmann, A., Depienne, C., Worbe, Y., Mir, P., Cath, D. C., Boomsma, D. I., Roessner, V., Wolanczyk, T., … Walitza, S. (2023). Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome. Translational Psychiatry, 13, 69. https://doi.org/10.1038/s41398-023-02341-5

Abstract

Tourette Syndrome (TS) is a complex neurodevelopmental disorder characterized by vocal and motor tics lasting more than a year. It is highly polygenic in nature with both rare and common previously associated variants. Epidemiological studies have shown TS to be correlated with other phenotypes, but large-scale phenome wide analyses in biobank level data have not been performed to date. In this study, we used the summary statistics from the latest meta-analysis of TS to calculate the polygenic risk score (PRS) of individuals in the UK