Publication: Effects of early and late diabetic neuropathy on sciatic nerve block duration and neurotoxicity in Zucker diabetic fatty rats
Effects of early and late diabetic neuropathy on sciatic nerve block duration and neurotoxicity in Zucker diabetic fatty rats
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Lirk, P., Verhamme, C., Boeckh, R., Stevens, M. F., ten Hoope, W., Gerner, P., Blumenthal, S., de Girolami, U., van Schaik, I. N., Hollmann, M. W., & Picardi, S. (2015). Effects of early and late diabetic neuropathy on sciatic nerve block duration and neurotoxicity in Zucker diabetic fatty rats. British Journal of Anaesthesia, 114(2), 319–326. https://doi.org/10.1093/bja/aeu270
Abstract
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Background The neuropathy of type II diabetes mellitus (DM) is increasing in prevalence worldwide. We aimed to test the hypothesis that in a rodent model of type II DM, neuropathy would lead to increased neurotoxicity and block duration after lidocaine-induced sciatic nerve block when compared with control animals. Methods Experiments were carried out in Zucker diabetic fatty rats aged 10 weeks (early diabetic) or 18 weeks (late diabetic, with or without insulin 3 units per day), and age-matched healthy controls. Left sciatic nerve bl
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- Lirk, P
- Verhamme, C
- Boeckh, R
- Stevens, M F
- ten Hoope, W
- Gerner, P
- Blumenthal, S
- de Girolami, U
- van Schaik, I N
- Hollmann, M W
- Picardi, S
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Lirk, P., Verhamme, C., Boeckh, R., Stevens, M. F., ten Hoope, W., Gerner, P., Blumenthal, S., de Girolami, U., van Schaik, I. N., Hollmann, M. W., & Picardi, S. (2015). Effects of early and late diabetic neuropathy on sciatic nerve block duration and neurotoxicity in Zucker diabetic fatty rats. British Journal of Anaesthesia, 114(2), 319–326. https://doi.org/10.1093/bja/aeu270
