Publication: Digoxin-induced retinal degeneration depends on rhodopsin
Digoxin-induced retinal degeneration depends on rhodopsin
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Landfried, B., Samardzija, M., Barben, M., Schori, C., Klee, K., Storti, F., & Grimm, C. (2017). Digoxin-induced retinal degeneration depends on rhodopsin. Cell Death and Disease, 8, e2670. https://doi.org/10.1038/cddis.2017.94
Abstract
Abstract
Abstract
Na,K-ATPases are energy consuming ion pumps that are required for maintaining ion homeostasis in most cells. In the retina, Na,K-ATPases are especially important to sustain the dark current in photoreceptor cells needed for rapid hyperpolarization of rods and cones in light. Cardiac glycosides like digoxin inhibit the activity of Na,K-ATPases by targeting their catalytic alpha subunits. This leads to a disturbed ion balance, which can affect cellular function and survival. Here we show that the treatment of wild-type mice with digoxin
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Creators (Authors)
- Landfried, Britta
- Samardzija, Marijana
- Barben, Maya
- Schori, Christian
- Klee, Katrin
- Storti, Federica
- Grimm, Christian
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Landfried, B., Samardzija, M., Barben, M., Schori, C., Klee, K., Storti, F., & Grimm, C. (2017). Digoxin-induced retinal degeneration depends on rhodopsin. Cell Death and Disease, 8, e2670. https://doi.org/10.1038/cddis.2017.94
