Publication: Xrp1 is a transcription factor required for cell competition-driven elimination of loser cells
Xrp1 is a transcription factor required for cell competition-driven elimination of loser cells
Date
Date
Date
Citations
Baillon, L., Germani, F., Rockel, C., Hilchenbach, J., & Basler, K. (2018). Xrp1 is a transcription factor required for cell competition-driven elimination of loser cells. Scientific Reports, 8(1), 17712. https://doi.org/10.1038/s41598-018-36277-4
Abstract
Abstract
Abstract
The elimination of unfit cells from a tissue is a process known in Drosophila and mammals as cell competition. In a well-studied paradigm "loser" cells that are heterozygous mutant for a haploinsufficient ribosomal protein gene are eliminated from developing tissues via apoptosis when surrounded by fitter wild-type cells, referred to as "winner" cells. However, the mechanisms underlying the induction of this phenomenon are not fully understood. Here we report that a CCAAT-Enhancer-Binding Protein (C/EBP), Xrp1, which is known to help
Additional indexing
Creators (Authors)
- Baillon, Ludovic
- Germani, Federico
- Rockel, Claudia
- Hilchenbach, Jochen
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Item Type
Item Type
Item Type
In collections
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Citations
Baillon, L., Germani, F., Rockel, C., Hilchenbach, J., & Basler, K. (2018). Xrp1 is a transcription factor required for cell competition-driven elimination of loser cells. Scientific Reports, 8(1), 17712. https://doi.org/10.1038/s41598-018-36277-4
