Publication: Endocannabinoid response to social stress in chronic non-medical prescription opioid users
Endocannabinoid response to social stress in chronic non-medical prescription opioid users
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Schmid, V. K., Quednow, B. B., Pellegata, D., Meier, P., Gertsch, J., & Kroll, S. (2025). Endocannabinoid response to social stress in chronic non-medical prescription opioid users. Psychopharmacology, 243(2), 427–441. https://doi.org/10.1007/s00213-025-06950-4
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Rationale The ongoing global opioid crisis underscores the need to better understand the neurobiological mechanisms underlying opioid use disorder (OUD). Stress is a key risk factor for developing and maintaining OUD. While animal models report that the endocannabinoid system (ECS) plays a modulatory role in stress response, alterations of ECS stress reactivity in individuals with OUD have yet to be studied. Objectives Here, we aimed to study the response of the ECS to experimentally-induced mild psychosocial stress in individuals wit
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Schmid, V. K., Quednow, B. B., Pellegata, D., Meier, P., Gertsch, J., & Kroll, S. (2025). Endocannabinoid response to social stress in chronic non-medical prescription opioid users. Psychopharmacology, 243(2), 427–441. https://doi.org/10.1007/s00213-025-06950-4
