Publication: From morphogen to morphogenesis and back
From morphogen to morphogenesis and back
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Gilmour, D., Rembold, M., & Leptin, M. (2017). From morphogen to morphogenesis and back. Nature, 541(7637), 311–320. https://doi.org/10.1038/nature21348
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A long-term aim of the life sciences is to understand how organismal shape is encoded by the genome. An important challenge is to identify mechanistic links between the genes that control cell-fate decisions and the cellular machines that generate shape, therefore closing the gap between genotype and phenotype. The logic and mechanisms that integrate these different levels of shape control are beginning to be described, and recently discovered mechanisms of cross-talk and feedback are beginning to explain the remarkable robustness of
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Gilmour, D., Rembold, M., & Leptin, M. (2017). From morphogen to morphogenesis and back. Nature, 541(7637), 311–320. https://doi.org/10.1038/nature21348