Publication: Intrakinetochore localization and essential functional domains of Drosophila Spc105
Intrakinetochore localization and essential functional domains of Drosophila Spc105
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Schittenhelm, R. B., Chaleckis, R., & Lehner, C. F. (2009). Intrakinetochore localization and essential functional domains of Drosophila Spc105. The EMBO Journal, 28(16), 2374–2386. https://doi.org/10.1038/emboj.2009.188
Abstract
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The kinetochore is assembled during mitotic and meiotic divisions within the centromeric region of chromosomes. It is composed of more than eighty different proteins. Spc105 (also designated as Spc7, KNL-1 or Blinkin in different eukaryotes) is a comparatively large kinetochore protein, which can bind to the Mis12/MIND and Ndc80 complexes and to the spindle assembly checkpoint components Bub1 and BubR1. Our genetic characterization of Drosophila Spc105 shows that a truncated version lacking the rapidly evolving, repetitive central thi
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- Schittenhelm, R B
- Chaleckis, R
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Schittenhelm, R. B., Chaleckis, R., & Lehner, C. F. (2009). Intrakinetochore localization and essential functional domains of Drosophila Spc105. The EMBO Journal, 28(16), 2374–2386. https://doi.org/10.1038/emboj.2009.188
