Publication: Long-term expression of TIMP1 in the murine CNS does not alter the morphological and behavioural phenotype but alleviates the course of EAE
Long-term expression of TIMP1 in the murine CNS does not alter the morphological and behavioural phenotype but alleviates the course of EAE
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Althoff, G. E. M., Wolfer, D. P., Timmesfeld, N., Kanzler, B., Schrewe, H., & Pagenstecher, A. (2010). Long-term expression of TIMP1 in the murine CNS does not alter the morphological and behavioural phenotype but alleviates the course of EAE. American Journal of Pathology, 2(177), 840–853. https://doi.org/10.2353/ajpath.2010.090918
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Tissue inhibitors of metalloproteinases (TIMPs) are a family of closely related proteins that inhibit matrix metalloproteinases (MMPs). In the central nervous system (CNS), TIMPs 2, 3, and 4 are constitutively expressed at high levels, whereas TIMP1 can be induced by various stimuli. Here, we studied the effects of constitutive expression of TIMP1 in the CNS in transgenic mice. Transgene expression started prenatally and persisted throughout lifetime at high levels. Since MMP activity has been implicated in CNS development, in proper
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- Althoff, G E M
- Wolfer, D P
- Timmesfeld, N
- Kanzler, B
- Schrewe, H
- Pagenstecher, A
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Althoff, G. E. M., Wolfer, D. P., Timmesfeld, N., Kanzler, B., Schrewe, H., & Pagenstecher, A. (2010). Long-term expression of TIMP1 in the murine CNS does not alter the morphological and behavioural phenotype but alleviates the course of EAE. American Journal of Pathology, 2(177), 840–853. https://doi.org/10.2353/ajpath.2010.090918