Publication: Transcriptomic and Functional Evidence for Differential Effects of MCF-7 Breast Cancer Cell-Secretome on Vascular and Lymphatic Endothelial Cell Growth
Transcriptomic and Functional Evidence for Differential Effects of MCF-7 Breast Cancer Cell-Secretome on Vascular and Lymphatic Endothelial Cell Growth
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Azzarito, G., Visentin, M., Leeners, B., & Dubey, R. K. (2022). Transcriptomic and Functional Evidence for Differential Effects of MCF-7 Breast Cancer Cell-Secretome on Vascular and Lymphatic Endothelial Cell Growth. International Journal of Molecular Sciences, 23(13), 7192. https://doi.org/10.3390/ijms23137192
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Vascular and lymphatic vessels drive breast cancer (BC) growth and metastasis. We assessed the cell growth (proliferation, migration, and capillary formation), gene-, and protein-expression profiles of Vascular Endothelial Cells (VECs) and Lymphatic Endothelial Cells (LECs) exposed to a conditioned medium (CM) from estrogen receptor-positive BC cells (MCF-7) in the presence or absence of Estradiol. We demonstrated that MCF-7-CM stimulated growth and capillary formation in VECs but inhibited LEC growth. Consistently, MCF-7-CM induced E
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- Azzarito, Giovanna
- Visentin, Michele
- Leeners, Brigitte
- Dubey, Raghvendra K
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Azzarito, G., Visentin, M., Leeners, B., & Dubey, R. K. (2022). Transcriptomic and Functional Evidence for Differential Effects of MCF-7 Breast Cancer Cell-Secretome on Vascular and Lymphatic Endothelial Cell Growth. International Journal of Molecular Sciences, 23(13), 7192. https://doi.org/10.3390/ijms23137192
