Publication: In Vitro and Ectopic In Vivo Studies toward the Utilization of Rapidly Isolated Human Nasal Chondrocytes for Single-Stage Arthroscopic Cartilage Regeneration Therapy
In Vitro and Ectopic In Vivo Studies toward the Utilization of Rapidly Isolated Human Nasal Chondrocytes for Single-Stage Arthroscopic Cartilage Regeneration Therapy
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Lehoczky, G., Trofin, R. E., Vallmajo‐Martin, Q., Chawla, S., Pelttari, K., Mumme, M., Haug, M., Egloff, C., Jakob, M., Ehrbar, M., Martin, I., & Barbero, A. (2022). In Vitro and Ectopic In Vivo Studies toward the Utilization of Rapidly Isolated Human Nasal Chondrocytes for Single-Stage Arthroscopic Cartilage Regeneration Therapy. International Journal of Molecular Sciences, 23(13), 6900. https://doi.org/10.3390/ijms23136900
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Abstract
Nasal chondrocytes (NCs) have a higher and more reproducible chondrogenic capacity than articular chondrocytes, and the engineered cartilage tissue they generate in vitro has been demonstrated to be safe in clinical applications. Here, we aimed at determining the feasibility for a single-stage application of NCs for cartilage regeneration under minimally invasive settings. In particular, we assessed whether NCs isolated using a short collagenase digestion protocol retain their potential to proliferate and chondro-differentiate within
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- Lehoczky, Gyözö
- Trofin, Raluca Elena
- Vallmajo‐Martin, Queralt
- Chawla, Shikha
- Pelttari, Karoliina
- Mumme, Marcus
- Haug, Martin
- Egloff, Christian
- Jakob, Marcel
- Martin, Ivan
- Barbero, Andrea
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Lehoczky, G., Trofin, R. E., Vallmajo‐Martin, Q., Chawla, S., Pelttari, K., Mumme, M., Haug, M., Egloff, C., Jakob, M., Ehrbar, M., Martin, I., & Barbero, A. (2022). In Vitro and Ectopic In Vivo Studies toward the Utilization of Rapidly Isolated Human Nasal Chondrocytes for Single-Stage Arthroscopic Cartilage Regeneration Therapy. International Journal of Molecular Sciences, 23(13), 6900. https://doi.org/10.3390/ijms23136900
