Publication: A specialized ODE integrator for the efficient computation of parameter sensitivities
A specialized ODE integrator for the efficient computation of parameter sensitivities
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Gonnet, P., Dimopoulos, S., Widmer, L., & Stelling, J. (2012). A specialized ODE integrator for the efficient computation of parameter sensitivities. BMC Systems Biology, 6, 46. https://doi.org/10.1186/1752-0509-6-46
Abstract
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Abstract
BACKGROUND: Dynamic mathematical models in the form of systems of ordinary differential equations (ODEs) play an important role in systems biology. For any sufficiently complex model, the speed and accuracy of solving the ODEs by numerical integration is critical. This applies especially to systems identification problems where the parameter sensitivities must be integrated alongside the system variables. Although several very good general purpose ODE solvers exist, few of them compute the parameter sensitivities automatically. RESULT
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- Gonnet, Pedro
- Dimopoulos, Sotiris
- Widmer, Lukas
- Stelling, Jörg
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Gonnet, P., Dimopoulos, S., Widmer, L., & Stelling, J. (2012). A specialized ODE integrator for the efficient computation of parameter sensitivities. BMC Systems Biology, 6, 46. https://doi.org/10.1186/1752-0509-6-46
