Publication: High-dimensional single-cell analysis reveals the immune signature of narcolepsy
High-dimensional single-cell analysis reveals the immune signature of narcolepsy
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Hartmann, F. J., Bernard-Valnet, R., Quériault, C., Mrdjen, D., Weber, L. M., Galli, E., Krieg, C., Robinson, M. D., Nguyen, X.-H., Dauvilliers, Y., Liblau, R. S., & Becher, B. (2016). High-dimensional single-cell analysis reveals the immune signature of narcolepsy. Journal of Experimental Medicine, 213(12), 2621–2633. https://doi.org/10.1084/jem.20160897
Abstract
Abstract
Abstract
Narcolepsy type 1 is a devastating neurological sleep disorder resulting from the destruction of orexin-producing neurons in the central nervous system (CNS). Despite its striking association with the HLA-DQB106:02 allele, the autoimmune etiology of narcolepsy has remained largely hypothetical. Here, we compared peripheral mononucleated cells from narcolepsy patients with HLA-DQB106:02-matched healthy controls using high-dimensional mass cytometry in combination with algorithm-guided data analysis. Narcolepsy patients displayed mult
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Creators (Authors)
- Hartmann, Felix J
- Bernard-Valnet, Raphaël
- Quériault, Clémence
- Mrdjen, Dunja
- Weber, Lukas M
- Galli, Edoardo
- Krieg, Carsten
- Nguyen, Xuan-Hung
- Dauvilliers, Yves
- Liblau, Roland S
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Citations
Hartmann, F. J., Bernard-Valnet, R., Quériault, C., Mrdjen, D., Weber, L. M., Galli, E., Krieg, C., Robinson, M. D., Nguyen, X.-H., Dauvilliers, Y., Liblau, R. S., & Becher, B. (2016). High-dimensional single-cell analysis reveals the immune signature of narcolepsy. Journal of Experimental Medicine, 213(12), 2621–2633. https://doi.org/10.1084/jem.20160897
