Publication: APPsα rescues Tau-induced synaptic pathology
APPsα rescues Tau-induced synaptic pathology
Date
Date
Date
Citations
Bold, C. S., Baltissen, D., Ludewig, S., Back, M. K., Just, J., Kilian, L., Erdinger, S., Banicevic, M., Rehra, L., Almouhanna, F., Nigri, M., Wolfer, D. P., Spilger, R., Rohr, K., Kann, O., Buchholz, C. J., von Engelhardt, J., Korte, M., & Müller, U. C. (2022). APPsα rescues Tau-induced synaptic pathology. Journal of Neuroscience, 42(29), 5782–5802. https://doi.org/10.1523/JNEUROSCI.2200-21.2022
Abstract
Abstract
Abstract
Alzheimer's disease (AD) is histopathologically characterized by Aβ plaques and the accumulation of hyperphosphorylated Tau species, the latter also constituting key hallmarks of primary tauopathies. Whereas Aβ is produced by amyloidogenic APP processing, APP processing along the competing non-amyloidogenic pathway results in the secretion of neurotrophic and synaptotrophic APPsα. Recently, we demonstrated that APPsα has therapeutic effects in transgenic AD model mice and rescues Aβ-dependent impairments. Here, we examined the potenti
Metrics
Views
Additional indexing
Creators (Authors)
Volume
Volume
Volume
Number
Number
Number
Page range/Item number
Page range/Item number
Page range/Item number
Page end
Page end
Page end
Item Type
Item Type
Item Type
In collections
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Dewey Decimal Classifikation
Language
Language
Language
Publication date
Publication date
Publication date
Date available
Date available
Date available
ISSN or e-ISSN
ISSN or e-ISSN
ISSN or e-ISSN
OA Status
OA Status
OA Status
Free Access at
Free Access at
Free Access at
Publisher DOI
Metrics
Views
Citations
Bold, C. S., Baltissen, D., Ludewig, S., Back, M. K., Just, J., Kilian, L., Erdinger, S., Banicevic, M., Rehra, L., Almouhanna, F., Nigri, M., Wolfer, D. P., Spilger, R., Rohr, K., Kann, O., Buchholz, C. J., von Engelhardt, J., Korte, M., & Müller, U. C. (2022). APPsα rescues Tau-induced synaptic pathology. Journal of Neuroscience, 42(29), 5782–5802. https://doi.org/10.1523/JNEUROSCI.2200-21.2022
