Publication: Sirtuin 5 as a novel target to blunt blood-brain barrier damage induced by cerebral ischemia/reperfusion injury
Sirtuin 5 as a novel target to blunt blood-brain barrier damage induced by cerebral ischemia/reperfusion injury
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Diaz-Cañestro, C., Merlini, M., Bonetti, N. R., Liberale, L., Wüst, P., Briand-Schumacher, S., Klohs, J., Costantino, S., Miranda, M., Schoedon-Geiser, G., Kullak-Ublick, G. A., Akhmedov, A., Paneni, F., Beer, J. H., Lüscher, T. F., & Camici, G. G. (2018). Sirtuin 5 as a novel target to blunt blood-brain barrier damage induced by cerebral ischemia/reperfusion injury. International Journal of Cardiology, 260, 148–155. https://doi.org/10.1016/j.ijcard.2017.12.060
Abstract
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BACKGROUND: In acute ischemic stroke (AIS) patients, impaired blood-brain barrier (BBB) integrity is associated with hemorrhagic transformation and worsened outcome. Yet, the mechanisms underlying these relationships are poorly understood and consequently therapeutic strategies are lacking. This study sought to determine whether SIRT5 contributes to BBB damage following I/R brain injury. METHODS AND RESULTS: SIRT5 knockout (SIRT5-/-) and wild type (WT) mice underwent transient middle cerebral artery (MCA) occlusion (tMCAO) followed by
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- Diaz-Cañestro, Candela
- Merlini, Mario
- Bonetti, Nicole R
- Liberale, Luca
- Wüst, Patricia
- Briand-Schumacher, Sylvie
- Klohs, Jan
- Costantino, Sara
- Miranda, Melroy
- Schoedon-Geiser, Gabriele
- Kullak-Ublick, Gerd A
- Akhmedov, Alexander
- Paneni, Francesco
- Beer, Jürg H
- Lüscher, Thomas F
- Camici, Giovanni G
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Diaz-Cañestro, C., Merlini, M., Bonetti, N. R., Liberale, L., Wüst, P., Briand-Schumacher, S., Klohs, J., Costantino, S., Miranda, M., Schoedon-Geiser, G., Kullak-Ublick, G. A., Akhmedov, A., Paneni, F., Beer, J. H., Lüscher, T. F., & Camici, G. G. (2018). Sirtuin 5 as a novel target to blunt blood-brain barrier damage induced by cerebral ischemia/reperfusion injury. International Journal of Cardiology, 260, 148–155. https://doi.org/10.1016/j.ijcard.2017.12.060
