Publication: Erythropoietin Produces a Dual Effect on Carotid Body Chemoreception in Male Rats
Erythropoietin Produces a Dual Effect on Carotid Body Chemoreception in Male Rats
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Arias-Reyes, C., Laouafa, S., Zubieta-DeUrioste, N., Joseph, V., Bairam, A., Schneider Gasser, E. M., & Soliz, J. (2021). Erythropoietin Produces a Dual Effect on Carotid Body Chemoreception in Male Rats. Frontiers in Pharmacology, 12, 727326. https://doi.org/10.3389/fphar.2021.727326
Abstract
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Abstract
Erythropoietin (EPO) regulates respiration under conditions of normoxia and hypoxia through interaction with the respiratory centers of the brainstem. Here we investigate the dose-dependent impact of EPO in the CB response to hypoxia and hypercapnia. We show, in isolated “en bloc” carotid body (CB) preparations containing the carotid sinus nerve (CSN) from adult male Sprague Dawley rats, that EPO acts as a stimulator of CSN activity in response to hypoxia at concentrations below 0.5 IU/ml. Under hypercapnic conditions, EPO did not inf
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- Arias-Reyes, Christian
- Laouafa, Sofien
- Zubieta-DeUrioste, Natalia
- Joseph, Vincent
- Bairam, Aida
- Schneider Gasser, Edith M
- Soliz, Jorge
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Arias-Reyes, C., Laouafa, S., Zubieta-DeUrioste, N., Joseph, V., Bairam, A., Schneider Gasser, E. M., & Soliz, J. (2021). Erythropoietin Produces a Dual Effect on Carotid Body Chemoreception in Male Rats. Frontiers in Pharmacology, 12, 727326. https://doi.org/10.3389/fphar.2021.727326
