Publication: Low Antituberculosis Drug Concentrations in HIV-Tuberculosis-Coinfected Adults with Low Body Weight: Is It Time To Update Dosing Guidelines?
Low Antituberculosis Drug Concentrations in HIV-Tuberculosis-Coinfected Adults with Low Body Weight: Is It Time To Update Dosing Guidelines?
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Sekaggya-Wiltshire, C., Chirehwa, M., Musaazi, J., von Braun, A., Buzibye, A., Muller, D., Gutteck, U., Motta, I., Calcagno, A., Fehr, J. S., Kambugu, A., Castelnuovo, B., Lamorde, M., & Denti, P. (2019). Low Antituberculosis Drug Concentrations in HIV-Tuberculosis-Coinfected Adults with Low Body Weight: Is It Time To Update Dosing Guidelines? Antimicrobial Agents and Chemotherapy, 63(6), online. https://doi.org/10.1128/aac.02174-18
Abstract
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ABSTRACT Antituberculosis drugs display large pharmacokinetic variability, which may be influenced by several factors, including body size, genetic differences, and drug-drug interactions. We set out to determine these factors, quantify their effect, and determine the dose adjustments necessary for optimal drug concentrations. HIV-infected Ugandan adults with pulmonary tuberculosis treated according to international weight-based dosing guidelines underwent pharmacokinetic sampling (1, 2, and 4 h after drug intake) 2, 8, and 24 weeks a
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- Sekaggya-Wiltshire, Christine
- Chirehwa, Maxwell
- Musaazi, Joseph
- von Braun, Amrei
- Buzibye, Allan
- Muller, Daniel
- Gutteck, Ursula
- Motta, Ilaria
- Calcagno, Andrea
- Fehr, Jan S
- Kambugu, Andrew
- Castelnuovo, Barbara
- Lamorde, Mohammed
- Denti, Paolo
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Sekaggya-Wiltshire, C., Chirehwa, M., Musaazi, J., von Braun, A., Buzibye, A., Muller, D., Gutteck, U., Motta, I., Calcagno, A., Fehr, J. S., Kambugu, A., Castelnuovo, B., Lamorde, M., & Denti, P. (2019). Low Antituberculosis Drug Concentrations in HIV-Tuberculosis-Coinfected Adults with Low Body Weight: Is It Time To Update Dosing Guidelines? Antimicrobial Agents and Chemotherapy, 63(6), online. https://doi.org/10.1128/aac.02174-18