Publication: GluA4 facilitates cerebellar expansion coding and enables associative memory formation
GluA4 facilitates cerebellar expansion coding and enables associative memory formation
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Kita, K., Albergaria, C., Machado, A. S., Carey, M. R., Müller, M., & Delvendahl, I. (2021). GluA4 facilitates cerebellar expansion coding and enables associative memory formation. ELife, 10, online. https://doi.org/10.7554/elife.65152
Abstract
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Abstract
AMPA receptors (AMPARs) mediate excitatory neurotransmission in the central nervous system (CNS) and their subunit composition determines synaptic efficacy. Whereas AMPAR subunits GluA1–GluA3 have been linked to particular forms of synaptic plasticity and learning, the functional role of GluA4 remains elusive. Here, we demonstrate a crucial function of GluA4 for synaptic excitation and associative memory formation in the cerebellum. Notably, GluA4-knockout mice had ~80% reduced mossy fiber to granule cell synaptic transmission. The fi
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- Kita, Katarzyna
- Albergaria, Catarina
- Machado, Ana S
- Carey, Megan R
- Delvendahl, Igor
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Kita, K., Albergaria, C., Machado, A. S., Carey, M. R., Müller, M., & Delvendahl, I. (2021). GluA4 facilitates cerebellar expansion coding and enables associative memory formation. ELife, 10, online. https://doi.org/10.7554/elife.65152
