Publication: Refinement of IntelliCage protocols for complex cognitive tasks through replacement of drinking restrictions by incentive-disincentive paradigms
Refinement of IntelliCage protocols for complex cognitive tasks through replacement of drinking restrictions by incentive-disincentive paradigms
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Ma, X., Schildknecht, B., Steiner, A. C., Amrein, I., Nigri, M., Bramati, G., & Wolfer, D. P. (2023). Refinement of IntelliCage protocols for complex cognitive tasks through replacement of drinking restrictions by incentive-disincentive paradigms. Frontiers in Behavioral Neuroscience, 17, 1232546. https://doi.org/10.3389/fnbeh.2023.1232546
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The IntelliCage allows automated testing of cognitive abilities of mice in a social home cage environment without handling by human experimenters. Restricted water access in combination with protocols in which only correct responses give access to water is a reliable learning motivator for hippocampus-dependent tasks assessing spatial memory and executive function. However, water restriction may negatively impact on animal welfare, especially in poor learners. To better comply with the 3R principles, we previously tested protocols in
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- Ma, Xueqian
- Schildknecht, Beatrice
- Steiner, Adrian C
- Amrein, Irmgard
- Nigri, Martina
- Bramati, Giulia
- Wolfer, David P
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Ma, X., Schildknecht, B., Steiner, A. C., Amrein, I., Nigri, M., Bramati, G., & Wolfer, D. P. (2023). Refinement of IntelliCage protocols for complex cognitive tasks through replacement of drinking restrictions by incentive-disincentive paradigms. Frontiers in Behavioral Neuroscience, 17, 1232546. https://doi.org/10.3389/fnbeh.2023.1232546
