Publication: Aglepristone decreases proliferation in progesterone receptor-positive canine mammary carcinomas
Aglepristone decreases proliferation in progesterone receptor-positive canine mammary carcinomas
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Guil-Luna, S., Sánchez-Céspedes, R., Millán, Y., De Andrés, F. J., Rollón, E., Domingo, V., Guscetti, F., & Martín de Las Mulas, J. (2011). Aglepristone decreases proliferation in progesterone receptor-positive canine mammary carcinomas. Journal of Veterinary Internal Medicine, 25, 518–523. https://doi.org/10.1111/j.1939-1676.2011.0723.x
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BACKGROUND:
Progesterone receptor (PR) antagonist aglepristone (RU534) has been used successfully for pregnancy termination and therapy of pyometra, vaginal tumors, and mammary hyperplasia in bitches and queens. All of these conditions share with canine mammary carcinomas the expression of PR. OBJECTIVES:
To study the effect of RU534 on proliferation and apoptosis in canine mammary carcinomas in relation to PR expression. ANIMALS:
Twenty-seven nonspayed bitches with mammary carcinomas were treated with either 2 doses of 20 mg/kg RU
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- Guil-Luna, S
- Sánchez-Céspedes, R
- Millán, Y
- De Andrés, F J
- Rollón, E
- Domingo, V
- Guscetti, Franco
- Martín de Las Mulas, J
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Guil-Luna, S., Sánchez-Céspedes, R., Millán, Y., De Andrés, F. J., Rollón, E., Domingo, V., Guscetti, F., & Martín de Las Mulas, J. (2011). Aglepristone decreases proliferation in progesterone receptor-positive canine mammary carcinomas. Journal of Veterinary Internal Medicine, 25, 518–523. https://doi.org/10.1111/j.1939-1676.2011.0723.x
