Publication: A rugged yet easily navigable fitness landscape
A rugged yet easily navigable fitness landscape
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Papkou, A., Garcia-Pastor, L., Escudero, J. A., & Wagner, A. (2023). A rugged yet easily navigable fitness landscape. Science, 382(6673), eadh3860. https://doi.org/10.1126/science.adh3860
Abstract
Abstract
Abstract
Fitness landscape theory predicts that rugged landscapes with multiple peaks impair Darwinian evolution, but experimental evidence is limited. In this study, we used genome editing to map the fitness of >260,000 genotypes of the key metabolic enzyme dihydrofolate reductase in the presence of the antibiotic trimethoprim, which targets this enzyme. The resulting landscape is highly rugged and harbors 514 fitness peaks. However, its highest peaks are accessible to evolving populations via abundant fitness-increasing paths. Different peak
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- Garcia-Pastor, Lucia
- Escudero, José Antonio
- Wagner, Andreas
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Papkou, A., Garcia-Pastor, L., Escudero, J. A., & Wagner, A. (2023). A rugged yet easily navigable fitness landscape. Science, 382(6673), eadh3860. https://doi.org/10.1126/science.adh3860
