Publication: Development of ArgTag for Scalable Solid-Phase Synthesis of Aggregating Peptides
Development of ArgTag for Scalable Solid-Phase Synthesis of Aggregating Peptides
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Freiburghaus, V., Jeandin, A., Frankiewicz, Ł., Yang, J., & Hartrampf, N. (2025). Development of ArgTag for Scalable Solid-Phase Synthesis of Aggregating Peptides. ACS Chemical Biology, 20(11), 2733–2740. https://doi.org/10.1021/acschembio.5c00662
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Aggregation during solid-phase peptide synthesis (SPPS) remains a key limitation, often leading to low coupling efficiencies and poor crude purities. Our previously introduced synthesis tag ("SynTag") for chemical protein synthesis combines six C-terminal Arg(Pbf) residues with a MeDbz linker to suppress aggregation via helical structure induction and serves as a handle for native chemical ligation (NCL). To apply the concept to short, yet aggregation-prone sequences, some practical limitations need to be addressed: Tag removal needs
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Freiburghaus, V., Jeandin, A., Frankiewicz, Ł., Yang, J., & Hartrampf, N. (2025). Development of ArgTag for Scalable Solid-Phase Synthesis of Aggregating Peptides. ACS Chemical Biology, 20(11), 2733–2740. https://doi.org/10.1021/acschembio.5c00662
